منابع مشابه
D-Titin
Previously, we reported that chromosomes contain a giant filamentous protein, which we identified as titin, a component of muscle sarcomeres. Here, we report the sequence of the entire titin gene in Drosophila melanogaster, D-Titin, and show that it encodes a two-megadalton protein with significant colinear homology to the NH(2)-terminal half of vertebrate titin. Mutations in D-Titin cause chro...
متن کاملMechanoenzymatics of titin kinase.
Biological responses to mechanical stress require strain-sensing molecules, whose mechanically induced conformational changes are relayed to signaling cascades mediating changes in cell and tissue properties. In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric M-band and contributes to the adaptation of musc...
متن کاملClash of the titin
In This Issue In This Issue Clash of the titin he sarcomere is more than a complicated piece of structural machinery. According to new results by McElhinny et al. (page 125), a building block of striated muscle cells called MURF-1 may also indirectly regulate gene expression. MURF-1 localizes to sarcomeres thanks to its interaction with titin, a major structural component of the muscle sarcomer...
متن کاملTitin isn't a sleeping giant
A t 3.7 MDa, titin is the largest protein known to exist (1). This giant polypeptide, also known as connectin, forms the backbone of striated muscle myofi brils by assembling the thin (actin) and thick (myosin) fi laments into periodic structural units called sarcomeres. One might expect such an enormous scaffold protein to be immobilized within myofi brils, but da Silva Lopes et al. reveal tha...
متن کاملCase Study: Titin Ig domains
In the extreme sport of bungee jumping, a daring athlete leaps from a great height and freefalls while a tethered cord tightens and stretches to absorb the energy from the descent. The bungee cord protects the jumper from serious injury, because its elasticity allows it to extend and provide a cushioning force that opposes gravity during the fall. Amazingly, nature also uses elasticity to dampe...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.104.14.1585